The Genome as a Commons

hunting woman 2

The right to graze your pigs in the forest, collect firewood, and to be genotyped

Magna Carta may get all the attention, but its poor cousin, the Charter of the Forest, deserves at least equal consideration. For one, it was the writing of the Charter of the Forest, two years after Magna Carta in 1215, that put the ‘Magna’ in Magna Carta. What we now call Magna Carta had been known at the time of its issuance as “The Articles of the Barons”, which sounds more like a polite euphemism in the castle laundry room for the barons’ undergarments  than something to keep in the history books. After the writing of the Charter of the Forests, so as to distinguish the two charters, Magna Carta received the title that helped ensured its Olympic enshrinement.

Secondly, the Charter of the Forest has a much more exciting vocabulary. The language of Magna Carta, dealing most with property and inheritance issues, was well within the staid grasp of the Latin in which it was written. But the Charter of the Forest deals with more down to earth issues, and it’s written in a delightful Anglo-Norman bastardization of Latin. One can almost imagine the clerks scratching their tonsured scalps, trying to figure out how to translate old English words like ‘swanimote’ (‘swain’+’moot’, a court held to decide on offences related to the forest), which they rendered in Latin as ‘suanimotum’. Or ‘pannage’ (the right to let one’s pigs browse in the forest), which possibly came to English via the French ‘pasnage’ via the Latin ‘pastionaticum’ (which also means letting pigs graze on acorns) but was rendered back into Latin in the Charter as ‘pannagium’. Or cheminage, which is the right to pass through a forest, and in its usage in the Charter, specifically with the intent of collecting wood , comes via the French ‘chemin’ (road), which is from the Latin caminus, but is rendered back into Latin in the Charter as chiminagium. I was brought by the lee in many a French test in high school via similar guesswork at what I hoped might be French, but possibly Madam Kessler was more exacting than whoever checked the work of King Henry’s clerks.

Finally, while Magna Carta mostly addressed grievances of the barons, the Charter of the Forest addressed those of the common person. Barons may outrank us commoners, but we decidedly trump them on sheer numbers. Take that word ‘cheminage’; the Charter says that a forester “may exact chiminage … only from those who come from outside his bailiwick … to buy wood, timber, bark, or charcoal and take them elsewhere to sell…. Those, on the other hand, who carry wood, bark, or charcoal on their backs for sale, although they get their living by it, shall not in future pay chiminage.” In other words, a forester cannot charge someone who comes into their forest to take out firewood, unless they don’t live in the neighborhood and can afford a donkey and a cart. Recalling when I lived in northern China with its cold winters (now we live on China’s more sultry southern shores), I can attest that come autumn an entire village’s economy may seem to be entirely based on gathering and accumulating large piles of sticks. Those carrying the bundles on their backs did not appear to be among the baronetcy.

Denying the existence of a commons transforms something from being a right of the community into a resource to be monetized.

In fact, the Charter of the Forest was one of the first legal documents to lay out our rights to the commons, that is, those parts of our community or neighborhood that we use not for commerce but to simply provide for ourselves. Collecting sticks in the woods, or letting your pigs graze on acorns, were aspects of the commons protected by the Charter. This was important from both an economic perspective as well as a societal one. Denying the existence of a commons transforms something from being a right of the community into a resource to be monetized by the few. Unfortunately we have proven to be better at the latter than protecting the former. However without the existence of commons, people are forced to change from being, well, just ‘people’, into ‘consumers’.

The advent of the science of genomics raises a new item that could be added to these charters. Is our genome a commons, or a resource? May we employ our genome on our own terms, or only on the terms set by companies, pharmacies, or the government? In terms of our genetics, are we destined for autonomy or dependence?

Continue Reading

Population genomics = Thousands and thousands of romance novels in one data set

http://www.kenniskennis.com/site/sculptures/Neanderthal%20Spy/

Genetics truly is the language of love

A key aspect of any decently lurid romantic novel is opposition. One lover is rich, the other poor. One is from the north, the other is from the south. One is demure, the other is brazen. The families don’t approve, secrecy is a must, and the threat of disclosure ever looms. The books shall have titles like “My Reluctant Pirate Lord”, “To Capture a Viscount”, or “Ancient gene flow from early modern humans into Eastern Neanderthals” (population genomic article titles tend to lack some of the allure of a proper romance novel, but make up for it with better equations).

The latter tale of forbidden loves was just published in the journal Nature, and it recounts about 100,000 years of romance. Figuring a generation every twenty years and that their tale covers Africa and Eurasia, this article covers a lot passion. And just like a romance novel- despite its basis in genetics and statistics- population genomics delves into the love borne of contradictions.

The elements of opposition in a population genetic story are, of course, genetic differences. Though dairy maid vs. marquise is more standard novel fare, genetics must focus on differences in our DNA. Fortunately there is plenty of genetic variation to assess, though much is undetectable without having your own Illumina MiSeq to sequence a genome or two. As discussed here, mitochondrial DNA is often used to trace relationships between groups of people. These mitochondrial mutations probably have little if any effect on our physiology. However by assaying these mutations in many different groups of people, we can trace how different populations flowed over time across the lands.

Continue Reading

The Galactic Midi-Chlorian Genome Project

starchild

The prophet Elisha vs Yoda: who had the highest midi-chlorian count?

Some of us, for whom the first Star Wars movies were a significant aspect of their youth, may have made more than a few furtive efforts during school trying to move objects using the Force. Luke could juggle swamp rocks, and Yoda could lift an X-wing. Surely I could move a pencil, especially during the bleaker moments of study hall, when time had ceased operating? But regrettably, no; I could not. Still, it was preferable to school work.

Yoda didn’t invent these exercises in telekinesis. It’s written in the Old Testament that Elisha, who was a disciple of Elijah, had a similar skill. The story is thus: Elisha was out one day with a guild of prophets, “sons of the prophets”, they were called.

An aside: a ‘guild of prophets’ is a funny organization to consider. Were there unlicensed prophets operating outside of the guild, recklessly forecasting the future without a single credential to their name? I like to imagine this band as a group of young guys for whom ‘I knew you were going to say that’ was their most common retort. Alas, unfortunately the term likely just refers to a group of priests.

Anyways, one of these prophets was chopping on a log and his axehead flew off the handle into the river. He immediately exclaimed, “Oh no, it was borrowed!” One must appreciate that this inconsequential detail (in the long run, at least) has been preserved for almost three thousand years. It suggests that, despite all our progress, loaning your tools to the neighbor has always been, and likely will always be, a fool’s practice. Fortunately Elisha was there, and throwing a stick into the river, he caused the axe to float to the surface. Yoda just needed to stretch out his hand to make Luke’s X-wing rise from the waters, but he was also holding a stick in the scene. I’m sure there is a significance in the conservation of the “stick” motif. For that matter, Yoda was a member of a guild of prophets, and his guild wore robes too. The similarities are striking, though before we declare that Yoda=Elisha we should acknowledge that there does not appear to be a Star Wars mirror to the biblical story of Elisha siccing two bears onto a pack of kids that were mocking his baldness.

Elisha’s miracle was granted via “gratia gratis data”, grace freely given to someone such that they can help others. Yoda explained his power differently, his came from ‘The Force’.

Presumably Elisha did this this miracle (the floating axe, not the one with the angry bears) via the grace of God, specifically through what’s termed in the church as “gratia gratis data”, grace freely given to someone such that they can help others. Yoda explained his power differently, his came from ‘The Force’. What the Force actually was… well that was a mystery. As is grace, for that matter.

Continue Reading