Surveyor-General of Genomes and Genes

surveyor general

Applications for the position are currently being accepted (not really)

Small things can become big things. Aeneas, fleeing from the destruction of his home town of Troy, fell in love with Dido, the queen of Carthage. That was a small thing, people fall in love all the time. Even I fell in love with Dido when, in her despair at finding that Aeneas was abandoning her to go found Rome, “Sleep fled her eyes, as quiet fled her mind. /Despair, and rage, and love divide her heart”.

That shouldn’t happen to anyone.

The news of their love affair was spread across the sea by Fama, the Roman goddess of gossip, rumor and fame. The bible says we’re supposed to love our enemies (and Crosby, Stills, Nash and Young say we’re supposed to love the one we’re with). The Aeneas and Dido affair was a case of prescient loving one’s enemy, for news of their aborted tryst, carried across the waters by Fama, led ultimately to the Punic wars (according to legend, at least). Virgil described Fama as, “at the start a small and cowardly thing, it soon puffs itself up, and walking upon the ground, buries its head in the clouds”. If you’ve ever read a copy of People’s magazine or Hello!, you know exactly what he meant about something small and inconsequential taking on giant proportions.

Surveys are collections of lots of small bits of information. William the Conqueror’s Domesday Book was one. The human genome project is another.

It’s not only gossip that can grow from the small to the large. Surveys are collections of many small facts and items of information; individually these facts are often inconsequential, but the survey may be greater than the sum of its parts. One of the first great surveys of public information was the Domesday survey, ordered by William the Conqueror of his new holdings in England. To make sure taxes and levies were correctly allotted, he ordered a survey of all the sources of income of the lords and counties. This included big things as well as the lesser. A coppice is a stand of small trees that is cut back periodically; the wood was used for baskets and barrels, poles and pikes, and whatever other uses one had of pliable wood before the advent of plastic and sheet metal, and in Domesday Book these are called silvia minutia, or ‘tiny woods’. A single coppice is not worth very much, but a single hamburger isn’t worth very much either, and yet McDonalds is worth over 100 billion dollars. Size may not matter, but numbers may. William had a lot of coppices, or at least, a number he felt was well worth counting.

A genomic sequence is another survey, with three billion entries per person. Even a simple survey of just a person’s most variable bits of their genome (since we are all 99.9% identical at the level of our genetic sequence) often has a million entries. Each entry in these surveys is a single base, just an A, C, T or G. Pretty small, and not very important.

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A Right To Stay Human?

being human

[insert ‘CRISPR’ pun here]

According to some accounts, many of our problems can be traced to this moment:

“By the seventh day God had finished the work he had been doing; so on the seventh day he rested from all his work.”

Many would agree that the world is basically good, as discussed on this site here, or at least better than many alternatives. However many would not argue against it needing a little fixing up. It’s run down a bit, and somethings probably need a complete rethink altogether. Mass global extinctions, suffering, and the platypus immediately come to mind, for example. As Yossarian said to Lieutenant Scheisskopf’s wife,

“And don’t tell me God works in mysterious ways…There’s nothing mysterious about it, He’s not working at all. He’s playing. Or else He’s forgotten all about us… What in the world was running through that warped, evil, scatological mind of His when He robbed old people of the power to control their bowel movements? Why in the world did He ever create pain?” 

Maybe Yossarian expresses this more strongly than necessary, but then he was under a lot of pressure, there being a war on and everyone trying to kill him. He knew they were trying to kill him because they kept shooting at him every time he flew a bombing mission.  His point is valid, however, many believe humankind could do with a little editing. For that matter, frogs, honeybees, the African elephant, and any other species on the verge of extinction could probably do with a helping hand.

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Not the clone army you’re looking for.

stormtrooper

Boethius, adviser to Theodoric the Great, king of the Ostrogoths, weighs in on the ethics of gene editing in human embryos

No news is good news.”

An oft repeated old saying, but when examined contains a pleasantly profound kernel: its unstated assumption is that “good” is the norm, and “bad” is the exception. Bad is newsworthy, good is commonplace. Grossly extrapolating on this, we could suppose this to mean that people might be inherently good as well. The bible claims, after all, that we’re made in the image of God. This was probably a good deal for us, though when I look in the mirror I fear God got the wrong end of the bargain. As Woody Allen wrote in Love and Death:

Boris: “You think I was made in God’s image? Take a look at me. You think He wears glasses?”
Sonja: “Not with those frames.

Of course one might suppose that using God’s image was aiming a bit too high for us, maybe an intelligent version of the panda would have been a less acrimonious and bellicose species to have dominion over this planet. Or maybe sentience was a bad idea all together for us. However, the story in Genesis concludes with the declaration, “ And God saw every thing that he had made, and, behold, it was very good.” So there’s that. Furthermore, several studies have suggested that people are intuitively cooperative, and that even infants prefer people who help others. Thus, even the cold light of science suggests that people are, basically, OK.

Nonetheless, despite this and the engineering adage, “if it ain’t broke, don’t fix it”, we can’t help but want to improve on ourselves. Again peaking into Genesis, self-improvement was the first temptation to humanity; the snake told Eve that if she and Adam ate the forbidden fruit “… you will be like God.”

That’s a hard proposition to pass on.

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